| |
|
|
 | Acesso ao texto completo restrito à biblioteca da Embrapa Alimentos e Territórios. Para informações adicionais entre em contato com mara.petrocchi@embrapa.br. |
|
Registro Completo |
|
Biblioteca(s): |
Embrapa Alimentos e Territórios. |
|
Data corrente: |
18/07/2023 |
|
Data da última atualização: |
16/11/2023 |
|
Tipo da produção científica: |
Artigo em Periódico Indexado |
|
Autoria: |
BEZERRA, J. N.; GOMEZ, M. C. V.; ROLÓN, M.; CORONEL, C.; ALMEIDA-BEZERRA, J. W.; FIDELIS, K. R.; MENEZES, S. A. de; CRUZ, R. P. da; DUARTE, A. E.; RIBEIRO, P. R. V.; BRITO, E. S. de; COUTINHO, H. D. M.; MORAIS-BRAGA, M. F. B.; BEZERRA, C. F. |
|
Afiliação: |
JÉSSICA NOGUEIRA BEZERRA, URCA; MARIA CELESTE VEGA GOMEZ, FUNDACIÓN MOISÉS BERTONI; MÍRIAN ROLÓN, FUNDACIÓN MOISÉS BERTONI; CATHIA CORONEL, FUNDACIÓN MOISÉS BERTONI; JOSÉ WEVERTON ALMEIDA-BEZERRA, UFPE; KLEBER RIBEIRO FIDELIS, UFPE; SAULO ALMEIDA DE MENEZES, UFPE; RAFAEL PEREIRA DA CRUZ, URCA; ANTÔNIA ELIENE DUARTE, URCA; PAULO RICELI VASCONCELOS RIBEIRO, CNAT; EDY SOUSA DE BRITO, CNAT; HENRIQUE DOUGLAS MELO COUTINHO, URCA; MARIA FLAVIANA BEZERRA MORAIS-BRAGA, URCA; CAMILA FONSECA BEZERRA, URCA. |
|
Título: |
Chemical composition, Evaluation of Antiparasitary and Cytotoxic Activity of the essential oil of Psidium brownianum MART EX. DC. |
|
Ano de publicação: |
2022 |
|
Fonte/Imprenta: |
Biocatalysis and Agricultural Biotechnology, v. 39, 102247, 2022. |
|
ISSN: |
1878-8181 |
|
DOI: |
https://doi.org/10.1016/j.bcab.2021.102247 |
|
Idioma: |
Inglês |
|
Conteúdo: |
Chagas Disease and Leishmaniasis are neglected parasitic diseases that constitute a major public health problem. In the search for new therapeutic alternatives for such pathologies, the essential oil of the leaves of Psidium brownianum Mart ex DC was investigated egarding its chemical composition, antiparasitic, and cytotoxic effects. The chemical composition of the oil was analyzed by gas chromatography coupled to mass spectrometry (GC/MS), showing two major constituents: Isogermafurene (52.93%) and Germacrone (16.02%). In antiparasitic activity, the oil was tested against the epimastigote forms of Trypanosoma cruzi, revealing 57.05% inhibition at the highest tested concentration (1000 μg/mL). In regard to antiparasitic activity against promastigote forms of Leishmania braziliensis and ishmania infantum, it obtained 92.61% and 84.16% inhibition, respectively, at the highest concentrations (1000 μg/mL). As for the cytotoxic effects, it showed high cytotoxicity, with IC50 = 328.9 μg/mL. The inhibitory concentration (IC50) obtained the best result for the promastigote forms of L. braziliensis (IC50 = 37.53 μg/mL), as well as the selectivity index (SI = 8.76). Such results generate perspectives for new research and may contribute to more effective drug discoveries. |
|
Palavras-Chave: |
Anti kinetoplastid; Antiparasitic; Citotóxicos; Doenças parasitárias; Efeito antiparasitário; Parasitic disease; Pathologies; Phytochemistry; Psidium brownianum Mart ex DC; Terapêutica alternativa; Therapeutic alternatives. |
|
Thesagro: |
Doença de Chagas; Leishmaniose; Myrtaceae; Óleo Vegetal; Saúde Pública. |
|
Thesaurus Nal: |
Chagas disease; Cytotoxicity; Public health; Vegetable oil. |
|
Categoria do assunto: |
H Saúde e Patologia |
|
Marc: |
LEADER 02922naa a2200541 a 4500
001 2155032
005 2023-11-16
008 2022 bl uuuu u00u1 u #d
022 $a1878-8181
024 7 $ahttps://doi.org/10.1016/j.bcab.2021.102247$2DOI
100 1 $aBEZERRA, J. N.
245 $aChemical composition, Evaluation of Antiparasitary and Cytotoxic Activity of the essential oil of Psidium brownianum MART EX. DC.$h[electronic resource]
260 $c2022
520 $aChagas Disease and Leishmaniasis are neglected parasitic diseases that constitute a major public health problem. In the search for new therapeutic alternatives for such pathologies, the essential oil of the leaves of Psidium brownianum Mart ex DC was investigated egarding its chemical composition, antiparasitic, and cytotoxic effects. The chemical composition of the oil was analyzed by gas chromatography coupled to mass spectrometry (GC/MS), showing two major constituents: Isogermafurene (52.93%) and Germacrone (16.02%). In antiparasitic activity, the oil was tested against the epimastigote forms of Trypanosoma cruzi, revealing 57.05% inhibition at the highest tested concentration (1000 μg/mL). In regard to antiparasitic activity against promastigote forms of Leishmania braziliensis and ishmania infantum, it obtained 92.61% and 84.16% inhibition, respectively, at the highest concentrations (1000 μg/mL). As for the cytotoxic effects, it showed high cytotoxicity, with IC50 = 328.9 μg/mL. The inhibitory concentration (IC50) obtained the best result for the promastigote forms of L. braziliensis (IC50 = 37.53 μg/mL), as well as the selectivity index (SI = 8.76). Such results generate perspectives for new research and may contribute to more effective drug discoveries.
650 $aChagas disease
650 $aCytotoxicity
650 $aPublic health
650 $aVegetable oil
650 $aDoença de Chagas
650 $aLeishmaniose
650 $aMyrtaceae
650 $aÓleo Vegetal
650 $aSaúde Pública
653 $aAnti kinetoplastid
653 $aAntiparasitic
653 $aCitotóxicos
653 $aDoenças parasitárias
653 $aEfeito antiparasitário
653 $aParasitic disease
653 $aPathologies
653 $aPhytochemistry
653 $aPsidium brownianum Mart ex DC
653 $aTerapêutica alternativa
653 $aTherapeutic alternatives
700 1 $aGOMEZ, M. C. V.
700 1 $aROLÓN, M.
700 1 $aCORONEL, C.
700 1 $aALMEIDA-BEZERRA, J. W.
700 1 $aFIDELIS, K. R.
700 1 $aMENEZES, S. A. de
700 1 $aCRUZ, R. P. da
700 1 $aDUARTE, A. E.
700 1 $aRIBEIRO, P. R. V.
700 1 $aBRITO, E. S. de
700 1 $aCOUTINHO, H. D. M.
700 1 $aMORAIS-BRAGA, M. F. B.
700 1 $aBEZERRA, C. F.
773 $tBiocatalysis and Agricultural Biotechnology$gv. 39, 102247, 2022.
Download
Esconder MarcMostrar Marc Completo |
|
Registro original: |
Embrapa Alimentos e Territórios (CNAT) |
|
|
Biblioteca |
ID |
Origem |
Tipo/Formato |
Classificação |
Cutter |
Registro |
Volume |
Status |
URL |
Voltar
|
|
|
| Registros recuperados : 1 | |
| 1. |  | LACERDA, V. A.; TRINDADE, R. dos S.; MARIZ, B. L.; PARRELLA, N. N. D.; GUIMARAES, P. E. de O.; GUIMARAES, L. J. M. Avaliação do desempenho agronômico de híbridos de milho na safrinha da região centro-sul do Brasil via modelos mistos. In: SEMINÁRIO DE INICIAÇÃO CIENTÍFICA PIBIC/CNPq, 19., 2021, Sete Lagoas. [Trabalhos apresentados]. Sete Lagoas: Embrapa Milho e Sorgo, 2021.| Tipo: Artigo em Anais de Congresso |
| Biblioteca(s): Embrapa Milho e Sorgo. |
|    |
| Registros recuperados : 1 | |
|
| Expressão de busca inválida. Verifique!!! |
|
|
